Home > Offer to Sell > Intermediates > Pharmaceutical intermediates > 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one
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| Post Date: | Mar 05,2015 |
| Expiry Date: | Mar 04,2016 |
| Detailed Description: |
Cas No. :196597-78-1
Quantity: 10Metric Tons What is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one? 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one is a key intermediate for preparation of ramelteon, a MT1 and MT2 melatonin receptor selective agonist. Brief introduction of ramelteon Previously, sleep agents bind to GABAA receptors which are associated with anxiolytic, myorelaxant, and amnesic effects, such as with drugs like zolpidem, eszopiclone, and zaleplon. As the first in a new class of sleep agents, Ramelteon selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN). It was developed by Takeda Pharmaceuticals North America with the trade name Rozerem, and was approved by the U.S. Food and Drug Administration (FDA) on July 4th, 2005 for long-term use. It can be used for insomnia, delayed sleep onset in particular. There is no proof showing that Ramelteon produces dependence and any potential for abuse. What's more, while there is withdrawal and rebound insomnia typically with GABA modulators, it is not shown in ramelteon. Ramelteon can also be used for the treatment of Delayed sleep phase syndrome. Ramelteon was proven by practice to be associated with a lower risk of delirium (3% vs 32%; P = .003). According to Chakraborti, D; Tampi, D. J.; Tampi, R. R. (2014) ( "Melatonin and Melatonin Agonist for Delirium in the Elderly Patients". American journal of Alzheimer's disease and other dementias), "ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo." |
| CAS Registry Number: | 196597-78-1 |
| Synonyms: | ;1,2,6,7-Tetrahydro-8H-indeno[5,4-β]furan-8-one; |
| Molecular Formula: | C11H10O2 |
| Molecular Weight: | 174.1959 |
| Molecular Structure: | ![196597-78-1 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one](https://images.chemnet.com/suppliers/chembase/cas/cas196597-78-1.gif)
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| Company: | Banff Green Technologies, Inc. [ China ] |
| Contact: | Xue Yang |
| Tel: | +862154795870 |
| Fax: | |
| Email: | banffgreentech@outlook.com |
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